Journal article
Association of cognitive function with glucose tolerance and trajectories of glucose tolerance over 12 years in the AusDiab study
KJ Anstey, K Sargent-Cox, R Eramudugolla, DJ Magliano, JE Shaw
Alzheimer S Research and Therapy | BMC | Published : 2015
Abstract
Introduction: We investigated the association between glucose tolerance status and trajectories of change in blood glucose, and cognitive function in adults aged 25 to 85. Methods: The sample (n = 4547) was drawn from a national, population-based cohort study in Australia (AusDiab). Fasting plasma glucose (FPG), glycated haemoglobin (HbA1c) and general health were assessed at 0, 5 and 12 years. Covariates included age, education, body mass index, blood pressure and physical activity. At 12 years, participants completed assessments of memory, processing speed and verbal ability. Results: Known diabetes at baseline was associated with slower processing speed at 12 years in both younger (25-59 ..
View full abstractGrants
Awarded by Bristol-Myers Squibb
Funding Acknowledgements
The AusDiab study, co-coordinated by the Baker IDI Heart and Diabetes Institute, gratefully acknowledges the support and assistance given by B. Atkins, B. Balkau, E. Barr, A. Cameron, S. Chadban, M. de Courten, D. Dunstan, A. Kavanagh, S. Murray, N. Owen, K. Polkinghorne, T. Welborn, P. Zimmet and all of the study participants. For funding or logistical support, the authors are grateful to the National Health and Medical Research Council (NHMRC grants 233200 and 1007544), the Australian Government Department of Health and Ageing, Abbott Australasia Pty Ltd, Alphapharm Pty Ltd, Amgen Australia, AstraZeneca, Bristol-Myers Squibb, City Health Centre-Diabetes Service-Canberra, Department of Health and Community Services-Northern Territory, Department of Health and Human Services-Tasmania, Department of Health-New South Wales, Department of Health-Western Australia, Department of Health-South Australia, Department of Human Services-Victoria, Diabetes Australia, Diabetes Australia Northern Territory, Eli Lilly Australia, Estate of the Late Edward Wilson, GlaxoSmithKline, Jack Brockhoff Foundation, Janssen-Cilag, Kidney Health Australia, Marian & FH Flack Trust, Menzies Research Institute, Merck Sharp & Dohme, Novartis Pharmaceuticals, Novo Nordisk Pharmaceuticals, Pfizer Pty Ltd, Pratt Foundation, Queensland Health, Roche Diagnostics Australia, Royal Prince Alfred Hospital, Sydney, Sanofi Aventis, sanofi-synthelabo, and the Victorian Government's OIS Program. KJA is funded by NHMRC Research Fellowship No. 1002560. JES is funded by NHMRC Research Fellowship No. 586623. The corresponding author (KJA) takes responsibility for the content of the article.